Research


Following are listed the current lines of research pursued by the ISOPROG-Somatolink Expert-Patients-for-Patients network along with the peer-reviewed published scientific work:
A. The molecular mechanisms used by growth factors secreted by cancer cells. This line of research have provided the following peer-reviewed scientific publications:
- Scalia P. and Williams, S.J. (2023). A Post-translational Modification–enhanced Pull-down Method to Study Degron Domains and the Associated Protein Degradation Complexes. Bio-protocol 13(18): e4816. DOI: 10.21769/BioProtoc.4816.
- Scalia P, Williams SJ, Suma A, Carnevale V. (2023).The DTX Protein family: an Emerging Set of Ubiquitin E3 Ligases in Cancer.Cells,12(13):1680. https://doi.org/10.3390/ cells12131680
- Scalia P, Williams SJ, Fujita-Yamaguchi YY (2023). The Human IGF2 Gene And Its Epigenetic & Transcriptional Regulation: At the Core of Developmental Growth and Tumorigenic Behavior. Biomedicines, 11(6):1655 Doi: 10.3390/biomedicines11061655
- Scalia P, Merali C, Barrero C, Suma A, Carnevale V, Merali S, Williams SJ. (2023) Novel Isoform DTX3c Associates with UBE2N-UBA1 and Cdc48/p97 as Part of the EphB4 Degradation Complex Regulated by the Autocrine IGF-II/IRASignal in Malignant Mesothelioma. Int J Mol Sci. Apr 17;24(8):7380. doi: 10.3390/ijms24087380. PMID: 37108544; PMCID: PMC10139083. https://doi.org/10.3390/ijms24087380
- Scalia P, Williams SJ, Fujita-Yamaguchi Y, Giordano A. Cell cycle control by the insulin-like growth factor signal: at the crossroad between cell growth and mitotic regulation. Cell Cycle. 2023 Jan;22(1):1-37. doi: 10.1080/15384101.2022.2108117
- Scalia, P., Maurancy, J., Giordano, A., Williams, S.J. Transcriptional and Post-Translational Control Mechanisms for EphB4 Expression in Physiology and Cancer Disease. 2021, 31(2), pp. 83–88
- Scalia, P.; Heart, E.; Doughty, A; Giordano, A; Williams, S.J. Vitronectin Negatively Regulates IGF-II-Induced Mitogenic Signaling and Migration Mediated By The Insulin Receptor Isoform-A. Int J Appl Biol Pharm, 11(3), 229-244, 2020
- Scalia, P., Giordano, A., Martini, C., Williams, S.J. Isoform-and paralog-switching in IR-signaling: When diabetes opens the gates to cancer. Biomolecules, 2020, 10(12), pp. 1–17, 1617
- Scalia, P.; Giordano, A.; Williams, S.J. The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: Actionable Perspectives (review). Cancers, 12(2), 366, 2020. Doi: 10.3390/cancers12020366
- Scalia P, Williams SJ, Giordano A. Core elements cloning, cis-elements mapping and serum regulation of the Human EphB4 Promoter: A Novel TATA-Less Inr/MTE/DPE-like Regulated Gene. Genes,10, 997, 2019. doi:10.3390/genes1012099
- Scalia P, Pandini G, Carnevale V, Giordano A, Williams SJ. Identification of a Novel EphB4 Phosphodegron Regulated by the Autocrine IGFII/IRA Axis in Malignant Mesothelioma. Oncogene, 38:5987-6001,2019. doi: 10.1038/s41388-019-0854-y
B. The optimization of biobanking and of “multi-omic” profiling driven by artificial intelligence in the oncology and human pathology fields. These studies have been conveyed in the following work:
- Scalia P and Williams SJ. An Expert Patients-for-Patients integrated Biobanking-CRO Operational Model For Sustainable Personalized Oncology. Biomedical Journal of Science and Technological Research, 2020 Published on March 11th; Doi 10.26717/BJSTR.2020.26.004367
- Scalia P (panel speaker). Actionable Molecular Oncology Targets in Tissue High Content Screening Platform: Moving Proteomics Profiling to the Patient Bed. Tissue Microarray Workshop in Quantitative Digital Proteomics in Pathology. Philadelphia, USA, Children Hospital of Philadelphia, University of Pennsylvania, Buerger Center, November 17, 2017
- Scalia P (Panel speaker). Combined use of Laser Capture Microdissection and Geno-transcriptomic Analysis for cancer fingerprinting. Convention on “The Evolution of Molecular Biology in Anatomic Pathology”, Palermo, Italy, Hospital ARNAS Civico, June 24th, 2015
- Scalia P (panel speaker). Biobanking of Solid Tumors for Research & in Predictive-Preventive Screening: Limits & Perspectives. Convention of the Regional Oncologic Network, Sicily, CEFPAS Campus, Caltanissetta, Italy, April 10th, 2015
- Scalia P and Lo Presti G. Synergistic Data Integration in the Age of Personalized Medicine. ESBB-LIMS Workshop, Milano, Italy, March 13-14, 2014.
C. The optimization of NGS panels for fingerprinting of patient-derived cancer cells towards treatments personalization, which study has been conveyed in the following scientific work:
- Scalia P, Williams SJ, Russo A, Giordano A. 2017. Actionable Molecular Targets in Cancer Liquid Biopsy (Chapter in Book), p 71-76. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution. Ed. Russo, Giordano & Rolfo. Humana Press, 2017
- Scalia P (panelist speaker). Oncogenomics and signaling pathways in the clonal evolution induced by drug- resistance in melanoma. 1stMediterranean congress on New Therapies in the Treatment of Melanoma. Palermo, Italy, Palazzo Steri, September 11th & 12th,2015
- Scalia, P; Williams, SJ; Ventura, E; Stanganelli, I; Giordano, A; Ferrau’, F; Asero, S. The Onco-genomic Landscape of Malignant Melanoma: The Tumor Microenvironment Comes Of Age. J Cancer Res Oncobiol Aug;3(3):130, 2020; doi 10.31021/JCRO.20203130