Research

Following are listed the current lines of research pursued by the ISOPROG-Somatolink Expert-Patients-for-Patients network along with the peer-reviewed published scientific work:

A. The molecular mechanisms used by growth factors secreted by cancer cells. This line of research have provided the following peer-reviewed scientific publications:

  1. Scalia P. and Williams, S.J. (2023). A Post-translational Modification–enhanced Pull-down Method to Study Degron Domains and the Associated Protein Degradation Complexes. Bio-protocol 13(18): e4816. DOI: 10.21769/BioProtoc.4816.
  1. Scalia P, Williams SJ, Suma A, Carnevale V. (2023).The DTX Protein family: an Emerging Set of Ubiquitin E3 Ligases in Cancer.Cells,12(13):1680. https://doi.org/10.3390/ cells12131680
  1. Scalia P, Williams SJ, Fujita-Yamaguchi YY (2023). The Human IGF2 Gene And Its Epigenetic & Transcriptional Regulation: At the Core of Developmental Growth and Tumorigenic Behavior. Biomedicines, 11(6):1655 Doi: 10.3390/biomedicines11061655
  1. Scalia P, Merali C, Barrero C, Suma A, Carnevale V, Merali S, Williams SJ. (2023) Novel Isoform DTX3c Associates with UBE2N-UBA1 and Cdc48/p97 as Part of the EphB4 Degradation Complex Regulated by the Autocrine IGF-II/IRASignal in Malignant Mesothelioma. Int J Mol Sci. Apr 17;24(8):7380. doi: 10.3390/ijms24087380. PMID: 37108544; PMCID: PMC10139083. https://doi.org/10.3390/ijms24087380
  1. Scalia P, Williams SJ, Fujita-Yamaguchi Y, Giordano A. Cell cycle control by the insulin-like growth factor signal: at the crossroad between cell growth and mitotic regulation. Cell Cycle. 2023 Jan;22(1):1-37. doi: 10.1080/15384101.2022.2108117
  1. Scalia, P., Maurancy, J., Giordano, A., Williams, S.J. Transcriptional and Post-Translational Control Mechanisms for EphB4 Expression in Physiology and Cancer Disease. 2021, 31(2), pp. 83–88
  1. Scalia, P.; Heart, E.; Doughty, A; Giordano, A; Williams, S.J. Vitronectin Negatively Regulates IGF-II-Induced Mitogenic Signaling and Migration Mediated By The Insulin Receptor Isoform-A. Int J Appl Biol Pharm, 11(3), 229-244, 2020 
  1. Scalia, P., Giordano, A., Martini, C., Williams, S.J. Isoform-and paralog-switching in IR-signaling: When diabetes opens the gates to cancer. Biomolecules, 2020, 10(12), pp. 1–17, 1617 
  1. Scalia, P.; Giordano, A.; Williams, S.J. The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: Actionable Perspectives (review). Cancers, 12(2), 366, 2020. Doi: 10.3390/cancers12020366
  1. Scalia P, Williams SJ, Giordano A. Core elements cloning, cis-elements mapping and serum regulation of the Human EphB4 Promoter: A Novel TATA-Less Inr/MTE/DPE-like Regulated Gene. Genes,10, 997, 2019. doi:10.3390/genes1012099
  1. Scalia P, Pandini G, Carnevale V, Giordano A, Williams SJ. Identification of a Novel EphB4 Phosphodegron Regulated by the Autocrine IGFII/IRA Axis in Malignant Mesothelioma. Oncogene, 38:5987-6001,2019. doi: 10.1038/s41388-019-0854-y

B. The optimization of biobanking and of “multi-omic” profiling driven by artificial intelligence in the oncology and human pathology fields. These studies have been conveyed in the following work:

  1. Scalia P and Williams SJ. An Expert Patients-for-Patients integrated Biobanking-CRO Operational Model For Sustainable Personalized Oncology. Biomedical Journal of Science and Technological Research, 2020 Published on March 11th; Doi 10.26717/BJSTR.2020.26.004367
  1. Scalia P (panel speaker). Actionable Molecular Oncology Targets in Tissue High Content Screening Platform: Moving Proteomics Profiling to the Patient Bed. Tissue Microarray Workshop in Quantitative Digital Proteomics in Pathology. Philadelphia, USA, Children Hospital of Philadelphia, University of Pennsylvania, Buerger Center, November 17, 2017
  1. Scalia P (Panel speaker). Combined use of Laser Capture Microdissection and Geno-transcriptomic Analysis for cancer fingerprinting. Convention on “The Evolution of Molecular Biology in Anatomic Pathology”, Palermo, Italy, Hospital ARNAS Civico, June 24th, 2015
  1. Scalia P (panel speaker). Biobanking of Solid Tumors for Research & in Predictive-Preventive Screening: Limits & Perspectives. Convention of the Regional Oncologic Network, Sicily, CEFPAS Campus, Caltanissetta, Italy, April 10th, 2015
  1. Scalia P and Lo Presti G. Synergistic Data Integration in the Age of Personalized Medicine. ESBB-LIMS Workshop, Milano, Italy, March 13-14, 2014.

C. The optimization of NGS panels for fingerprinting of patient-derived cancer cells towards treatments personalization, which study has been conveyed in the following scientific work:

  1. Scalia P, Williams SJ, Russo A, Giordano A. 2017. Actionable Molecular Targets in Cancer Liquid Biopsy (Chapter in Book), p 71-76. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution. Ed. Russo, Giordano & Rolfo. Humana Press, 2017
  1. Scalia P (panelist speaker). Oncogenomics and signaling pathways in the clonal evolution induced by drug- resistance in melanoma. 1stMediterranean congress on New Therapies in the Treatment of Melanoma. Palermo, Italy, Palazzo Steri, September 11th & 12th,2015
  1. Scalia, P; Williams, SJ; Ventura, E; Stanganelli, I; Giordano, A; Ferrau’, F; Asero, S. The Onco-genomic Landscape of Malignant Melanoma: The Tumor Microenvironment Comes Of Age. J Cancer Res Oncobiol Aug;3(3):130, 2020; doi 10.31021/JCRO.20203130
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