The Research Projects proposed and self-funded by the ISOPROG-Somatolink EPFP network relate to:
A. The molecular mechanisms used by cancer secreted factors to affect tumor microenvironment towards the acquisition and maintenance of malignant features and their targeting in personalized medicine strategies.
The scientific work dedicated to this line of research has provided the following results:
- Scalia P, Pandini G, Carnevale V, Giordano A, Williams SJ. Identification of a Novel EphB4 Phosphodegron Regulated by the Autocrine IGFII/IRA Axis in Malignant Mesothelioma. Oncogene, 38:5987-6001,2019. doi: 10.1038/s41388-019-0854-y
- Scalia P, Williams SJ, Giordano A. Core elements cloning, cis-elements mapping and serum regulation of the Human EphB4 Promoter: A Novel TATA-Less Inr/MTE/DPE-like Regulated Gene. Genes,10, 997, 2019. doi:10.3390/genes1012099
- Scalia, P.; Giordano, A.; Williams, S.J. The IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer: Actionable Perspectives (review). Cancers, 12(2), 366, 2020. Doi: 10.3390/cancers12020366
- Scalia, P.; Heart, E.; Doughty, A; Giordano, A; Williams, S.J. Vitronectin Negatively Regulates IGF-II-Induced Mitogenic Signaling and Migration Mediated By The Insulin Receptor Isoform-A. Int J Appl Biol Pharm, 11(3), 229-244, 2020.
B. The optimization of biobanking processes towards A.I.-guided bio-genomic profiling in oncology and human disease. The scientific work dedicated to this line of research has provided the following results:
- Scalia P and Williams SJ. An Expert Patients-for-Patients integrated Biobanking-CRO Operational Model For Sustainable Personalized Oncology. Biomedical Journal of Science and Technological Research, 2020 Published on March 11th; Doi 10.26717/BJSTR.2020.26.004367
- Scalia P (panel speaker). Actionable Molecular Oncology Targets in Tissue High Content Screening Platform: Moving Proteomics Profiling to the Patient Bed. Tissue Microarray Workshop in Quantitative Digital Proteomics in Pathology. Philadelphia, USA, Children Hospital of Philadelphia, University of Pennsylvania, Buerger Center, November 17, 2017
- Scalia P (Panel speaker). Combined use of Laser Capture Microdissection and Geno-transcriptomic Analysis for cancer fingerprinting. Convention on “The Evolution of Molecular Biology in Anatomic Pathology”, Palermo, Italy, Hospital ARNAS Civico, June 24th, 2015
- Scalia P (panel speaker). Biobanking of Solid Tumors for Research & in Predictive-Preventive Screening: Limits & Perspectives. Convention of the Regional Oncologic Network, Sicily, CEFPAS Campus, Caltanissetta, Italy, April 10th, 2015
C. The optimization of NGS panels for the fingerprinting of patients’ derived cancer cells based upon the team-validated cancer-driver targets. The scientific work dedicated to this line of research has provided the following results:
- Scalia P, Williams SJ, Russo A, Giordano A. 2017. Actionable Molecular Targets in Cancer Liquid Biopsy (Chapter in Book), p 71-76. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution. Ed. Russo, Giordano & Rolfo. Humana Press, 2017
- Scalia P (panelist speaker). Oncogenomics and signaling pathways in the clonal evolution induced by drug- resistance in melanoma. 1stMediterranean congress on New Therapies in the Treatment of Melanoma. Palermo, Italy, Palazzo Steri, September 11th & 12th,2015
- Scalia, P; Williams, SJ; Ventura, E; Stanganelli, I; Giordano, A; Ferrau’, F; Asero, S. The Onco-genomic Landscape of Malignant Melanoma: The Tumor Microenvironment Comes Of Age. J Cancer Res Oncobiol Aug;3(3):130, 2020; doi 10.31021/JCRO.20203130
D. Integration of data derived from the individual patient towards deep personalized profiling. The scientific work dedicated to this line of research has provided the following results:
- Scalia P and Lo Presti G. Synergistic Data Integration in the Age of Personalized Medicine. ESBB-LIMS Workshop, Milano, Italy, March 13-14, 2014.
Updated on 2020-08-29T07:34:34+02:00, by .